ANDRE FILIPE DE MORAES BATISTA
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Artigo Científico Neonatal mortality prediction with routinely collected data: a machine learning approach(2021) ANDRE FILIPE DE MORAES BATISTA; Diniz, Carmen S. G.; Bonilha, Eliana A.; Kawachi, Ichiro; Chiavegatto Filho, Alexandre D. P.Background: Recent decreases in neonatal mortality have been slower than expected for most countries. This study aims to predict the risk of neonatal mortality using only data routinely available from birth records in the largest city of the Americas. Methods: A probabilistic linkage of every birth record occurring in the municipality of São Paulo, Brazil, between 2012 e 2017 was performed with the death records from 2012 to 2018 (1,202,843 births and 447,687 deaths), and a total of 7282 neonatal deaths were identified (a neonatal mortality rate of 6.46 per 1000 live births). Births from 2012 and 2016 (N = 941,308; or 83.44% of the total) were used to train five different machine learning algorithms, while births occurring in 2017 (N = 186,854; or 16.56% of the total) were used to test their predictive performance on new unseen data. Results: The best performance was obtained by the extreme gradient boosting trees (XGBoost) algorithm, with a very high AUC of 0.97 and F1-score of 0.55. The 5% births with the highest predicted risk of neonatal death included more than 90% of the actual neonatal deaths. On the other hand, there were no deaths among the 5% births with the lowest predicted risk. There were no significant differences in predictive performance for vulnerable subgroups. The use of a smaller number of variables (WHO’s five minimum perinatal indicators) decreased overall performance but the results still remained high (AUC of 0.91). With the addition of only three more variables, we achieved the same predictive performance (AUC of 0.97) as using all the 23 variables originally available from the Brazilian birth records. Conclusion: Machine learning algorithms were able to identify with very high predictive performance the neonatal mortality risk of newborns using only routinely collected data.Artigo Científico Data Leakage in Health Outcomes Prediction With Machine Learning. Comment on “Prediction of Incident Hypertension Within the Next Year: Prospective Study Using Statewide Electronic Health Records and Machine Learning"(2021) Chiavegatto Filho, Alexandre; ANDRE FILIPE DE MORAES BATISTA; Santos, Hellen Geremias dosArtigo Científico Cause-specific mortality prediction in older residents of São Paulo, Brazil: a machine learning approach(2021) Nascimento, Carla Ferreira do; Hellen Geremias dos Santos; ANDRE FILIPE DE MORAES BATISTA; Lay, Alejandra Andrea Roman; Duarte, Yeda Aparecida OliveiraBackground: Populational ageing has been increasing in a remarkable rate in developing countries. In this scenario, preventive strategies could help to decrease the burden of higher demands for healthcare services. Machine learning algorithms have been increasingly applied for identifying priority candidates for preventive actions, presenting a better predictive performance than traditional parsimonious models. Methods: Data were collected from the Health, Well Being and Aging (SABE) Study, a representative sample of older residents of São Paulo, Brazil. Machine learning algorithms were applied to predict death by diseases of respiratory system (DRS), diseases of circulatory system (DCS), neoplasms and other specific causes within 5 years, using socioeconomic, demographic and health features. The algorithms were trained in a random sample of 70% of subjects, and then tested in the other 30% unseen data. Results: The outcome with highest predictive performance was death by DRS (AUC−ROC = 0.89), followed by the other specific causes (AUC−ROC = 0.87), DCS (AUC−ROC = 0.67) and neoplasms (AUC−ROC = 0.52). Among only the 25% of individuals with the highest predicted risk of mortality from DRS were included 100% of the actual cases. The machine learning algorithms with the highest predictive performance were light gradient boosted machine and extreme gradient boosting. Conclusion: The algorithms had a high predictive performance for DRS, but lower for DCS and neoplasms. Mortality prediction with machine learning can improve clinical decisions especially regarding targeted preventive measures for older individuals.