FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4+ T regulatory cells

Página do item simplificado
dc.contributor.authorBraga, Walter Moises Tobias
dc.contributor.authorSilva, Bruna Raphaeli da
dc.contributor.authorCarvalho, Ana Carolina de
dc.contributor.authorMaekawa, Yumi H.
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorRizzatti, Edgar Gil
dc.contributor.authorAtanackovic, Djordje
dc.contributor.authorColleoni, Gisele Wally Braga
dc.coverage.paisAlemanhapt_BR
dc.creatorBraga, Walter Moises Tobias
dc.creatorSilva, Bruna Raphaeli da
dc.creatorCarvalho, Ana Carolina de
dc.creatorMaekawa, Yumi H.
dc.creatorRizzatti, Edgar Gil
dc.creatorAtanackovic, Djordje
dc.creatorColleoni, Gisele Wally Braga
dc.date.accessioned2022-08-15T14:24:46Z
dc.date.available2022-08-15T14:24:46Z
dc.date.issued2014
dc.description.otherIntroduction Multiple myeloma (MM) development involves a series of genetic abnormalities and changes in the bone marrow (BM) microenvironment, favoring the growth of the tumor and failure of local immune control. T regulatory (Treg) cells play an important role in dampening anti-tumor immune responses while T-helper-17 (Th17) cells seem to be critical for the eradication of malignant cells. The aim of our study was to characterize the expression of Treg- and Th17-related genes in total myeloma BM samples to assess their role as biomarkers, prognostic factors, and possible therapeutic targets in this incurable disease. Methods Expression of markers for Treg (FOXP3, CTLA4) and Th17 cells (RORγt) was determined by quantitative real-time PCR in BM aspirates of 46 MM patients, four patients with monoclonal gammopathy of undetermined significance, five solitary plasmacytomas, and five healthy BM donors. Gene expression was evaluated regarding an influence on the patients’ overall survival (OS). Results FOXP3 and CTLA4 presented a sixfold (p = 0.02) and 30-fold higher expression (p = 0.03), respectively, in MM patients than in controls. RORγt expression was similar in MM patients and controls. Median OS of MM patients was 16.8 (range 4.5–29.1) months, and international staging system was the only independent prognostic factor for patients survival. Conclusions Overexpression of FOXP3 and CTLA4 in total BM samples suggests a local accumulation of immunosuppressive Tregs, the MM tumor environment, possibly dampening anti-tumor host immune responses. Therapeutic approaches targeting Treg cells and restoring local anti-tumor immunity may provide new treatment strategies for this incurable malignancy.pt_BR
dc.format.extentp. 1189–1197pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doi10.1007/s00262-014-1589-9pt_BR
dc.identifier.issn1432-0851pt_BR
dc.identifier.issn0340-7004pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/3985
dc.identifier.volume63pt_BR
dc.language.isoInglêspt_BR
dc.publisherSpringerpt_BR
dc.relation.ispartofCancer Immunology, Immunotherapy volumept_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITORpt_BR
dc.subject.keywordsMultiple myelomapt_BR
dc.subject.keywordsFOXP3pt_BR
dc.subject.keywordsCTLA4pt_BR
dc.subject.keywordsTregpt_BR
dc.subject.keywordsTherapypt_BR
dc.titleFOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4+ T regulatory cellspt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://link.springer.com/article/10.1007/s00262-014-1589-9
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d

Arquivos

Pacote original

Agora exibindo 1 - 2 de 2
N/D
Nome:
Artigo_2014_FOXP3 and CTLA4 overexpression.pdf
Tamanho:
590.54 KB
Formato:
Adobe Portable Document Format
Descrição:
Artigo_2014_FOXP3 and CTLA4 overexpression
Baixar
Imagem de Miniatura
Nome:
Acesso_Primeira Pagina_FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4+ T regulatory cells.pdf
Tamanho:
158.74 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
N/D
Nome:
license.txt
Tamanho:
282 B
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

Coleção de Artigos Acadêmicos