Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?

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dc.contributor.authorBraga, Walter MT
dc.contributor.authorSilva, Bruna R da
dc.contributor.authorAlves, Veruska LF
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorAtanackovic, Djordje
dc.contributor.authorColleoni, Gisele WB
dc.coverage.paisReino Unidopt_BR
dc.creatorBraga, Walter MT
dc.creatorSilva, Bruna R da
dc.creatorAlves, Veruska LF
dc.creatorAtanackovic, Djordje
dc.creatorColleoni, Gisele WB
dc.date.accessioned2022-08-15T14:37:43Z
dc.date.available2022-08-15T14:37:43Z
dc.date.issued2014
dc.description.notesPRELIMINARY COMMUNICATIONpt_BR
dc.description.otherAim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor‐infiltrating T cells. Materials & methods:MAGE‐C1/CT‐7, MAGEA3/6, NY‐ESO‐1, LAGE‐1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT‐PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results:MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4+ T‐cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4+ T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MMpt_BR
dc.format.extentp. 569pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doihttps://doi.org/10.2217/imt.14.24pt_BR
dc.identifier.issn1750-743Xpt_BR
dc.identifier.issn1750-7448pt_BR
dc.identifier.issue5pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/3986
dc.identifier.volume6pt_BR
dc.language.isoInglêspt_BR
dc.publisherFuture Medicinept_BR
dc.relation.ispartofImmunotherapypt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITORpt_BR
dc.subject.keywordscancer/testis antigenpt_BR
dc.subject.keywordsmultiple myelomapt_BR
dc.subject.keywordsTh17pt_BR
dc.subject.keywordsTregpt_BR
dc.titleIs there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?pt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://www.futuremedicine.com/doi/epub/10.2217/imt.14.24
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d

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