Apolipoprotein E genotype is related to nitric oxide production in platelets

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dc.contributor.authorRINALDO ARTES
dc.contributor.authorMarcourakis, Tania
dc.contributor.authorBahia, Valéria S.
dc.contributor.authorKawamoto, Elisa M.
dc.contributor.authorNitrini, Ricardo
dc.contributor.authorCaramelli, Paulo
dc.contributor.authorKok, Fernando
dc.contributor.authorScavone, Cristoforo
dc.contributor.authorCuri, Rui
dc.contributor.authorMunhoz, Carolina D.
dc.contributor.authorGorjão, Renata
dc.coverage.paisEstados Unidospt_BR
dc.creatorMarcourakis, Tania
dc.creatorBahia, Valéria S.
dc.creatorKawamoto, Elisa M.
dc.creatorNitrini, Ricardo
dc.creatorCaramelli, Paulo
dc.creatorKok, Fernando
dc.creatorScavone, Cristoforo
dc.creatorCuri, Rui
dc.creatorMunhoz, Carolina D.
dc.creatorGorjão, Renata
dc.date.accessioned2022-08-19T13:51:54Z
dc.date.available2022-08-19T13:51:54Z
dc.date.issued2008
dc.description.notesTexto completopt_BR
dc.description.otherThe presence of the e4 allele of apolipoprotein E (APOE) is considered a risk factor for sporadic Alzheimer’s disease (AD). Our recent data demonstrated that the systemic modulation of oxidative stress in platelets and erythrocytes is disrupted in aging and AD. In this study, the relationship between APOE genotype and oxidative stress markers, both in AD patients and controls, was evaluated. The AD group showed an increase in the content of thiobarbituric acid-reactive substances (TBARS) and in the activities of nitric oxide synthase (NOS) and Na, K-ATPase, when compared to controls. Both groups had a similar cGMP content and superoxide dismutase activity. APOE e4 allele carriers showed higher NOS activity than non-carriers. These results suggest a possible influence of APOE genotype on nitric oxide (NO) production that might enhance the effects of age-related specific factor(s) associated with neurodegenerative disorders.pt_BR
dc.format.extentp. 852-858pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doihttp://dx.doi.org/10.1002/cbf.1516pt_BR
dc.identifier.issn10990844pt_BR
dc.identifier.issue8pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/4047
dc.identifier.volume26pt_BR
dc.language.isoInglêspt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.relation.ispartofCell Biochemistry and Functionpt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITORpt_BR
dc.subject.keywordsapolipoprotein Ept_BR
dc.subject.keywordsnitric oxidept_BR
dc.subject.keywordsoxidative stresspt_BR
dc.subject.keywordsperipheral biomarkerspt_BR
dc.subject.keywordsAlzheimer’s diseasept_BR
dc.titleApolipoprotein E genotype is related to nitric oxide production in plateletspt_BR
dc.typejournal article
dspace.entity.typePublication
local.subject.cnpqCiências Biológicaspt_BR
local.subject.cnpqCiências Exatas e da Terrapt_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublication8b791c94-f3e5-4e04-af26-594195a8f576
relation.isAuthorOfPublication.latestForDiscovery8b791c94-f3e5-4e04-af26-594195a8f576

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