Estimation of the tissue composition of the tumour mass in neuroblastoma using segmented CT images

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dc.contributor.authorFABIO JOSE AYRES
dc.contributor.authorM. K. Zuffo,
dc.contributor.authorRangayyan, R. M.
dc.contributor.authorBoag, G. S.
dc.contributor.authorO. Filho, V.
dc.contributor.authorValente , M.
dc.creatorM. K. Zuffo,
dc.creatorRangayyan, R. M.
dc.creatorBoag, G. S.
dc.creatorO. Filho, V.
dc.creatorValente , M.
dc.date.accessioned2024-11-12T19:17:06Z
dc.date.available2024-11-12T19:17:06Z
dc.date.issued2004
dc.description.abstractNeuroblastoma is the most common extra-cranial, solid, malignant tumour in children. Advances in radiology have made possible the detection and staging of the disease. Nevertheless, there is no method available at present that can go beyond detection and qualitative analysis, towards quantitative assessment of the tissues composition of the primary tumour mass in neuroblastoma. Such quantitative analysis could provide important information and serve as a decision-support tool to the radiologist and the oncologist, result in better treatment and follow-up and even lead to the avoidance of delayed surgery. The problem investigated was the improvement of the analysis of the primary tumour mass, in patients with neuroblastoma, using X-ray computed tomography (CT) images. A methodology was proposed for the estimation of the tissue content of the mass: it comprised a Gaussian mixture model for estimation, from segmented CT images, of the tissue composition of the primary tumour. To demonstrate the potential of the method, the results are presented of its application to ten CT examinations of four patients. The method provides quantitative information, and it was observed that the tumour in one of the patients reduced from 523 cm3 to 81 cm3 in volume, with an increase in calcification from about 20% to about 88% of the tumour volume, in response to chemotherapy over a period of five months. Results indicate that the proposed technique may be of considerable value in assessing the response to therapy of patients with neuroblastoma.en
dc.formatDigital
dc.format.extentp. 366 – 377
dc.identifier.doi10.1007/BF02344713
dc.identifier.issn1741-0444
dc.identifier.issn0140-0118
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/7216
dc.language.isoInglês
dc.relation.ispartofMedical and Biological Engineering and Computing
dc.subjectNeuroblastomaen
dc.subjectCT image analysisen
dc.subjectGaussian mixture modelen
dc.subjectTumour analysisen
dc.subjectTissue compositionen
dc.titleEstimation of the tissue composition of the tumour mass in neuroblastoma using segmented CT images
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://link.springer.com/article/10.1007/BF02344713
local.publisher.countryNão Informado
local.subject.cnpqCIENCIAS DA SAUDE::MEDICINA
local.subject.cnpqCIENCIAS DA SAUDE::MEDICINA::RADIOLOGIA MEDICA
local.subject.cnpqCIENCIAS DA SAUDE::MEDICINA::SAUDE MATERNO-INFANTIL
local.subject.cnpqENGENHARIAS::ENGENHARIA BIOMEDICA
local.subject.cnpqCIENCIAS BIOLOGICAS::BIOFISICA
local.typeArtigo Científico
publicationvolume.volumeNumber42
relation.isAuthorOfPublication37971022-7c69-4e93-9186-4c9431a1f95c
relation.isAuthorOfPublication.latestForDiscovery37971022-7c69-4e93-9186-4c9431a1f95c
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