Data-driven decision making for the screening of cognitive impairment in primary care: a machine learning approach using data from the ELSA-Brasil study

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dc.contributor.authorSzlejf, C.
dc.contributor.authorANDRE FILIPE DE MORAES BATISTA
dc.contributor.authorBertola, L.
dc.contributor.authorLotufo, P.A.
dc.contributor.authorBenseñor, I.M.
dc.contributor.authorChiavegatto Filho, A.D.P.
dc.contributor.authorSuemoto, C.K.
dc.creatorSzlejf, C.
dc.creatorBertola, L.
dc.creatorLotufo, P.A.
dc.creatorBenseñor, I.M.
dc.creatorChiavegatto Filho, A.D.P.
dc.creatorSuemoto, C.K.
dc.date.accessioned2024-11-19T22:42:18Z
dc.date.available2024-11-19T22:42:18Z
dc.date.issued2023
dc.description.abstractThe systematic assessment of cognitive performance of older people without cognitive complaints is controversial and unfeasible. Identifying individuals at higher risk of cognitive impairment could optimize resource allocation. We aimed to develop and test machine learning models to predict cognitive impairment using variables obtainable in primary care settings. In this cross-sectional study, we included 8,291 participants of the baseline assessment of the ELSA-Brasil study, who were aged between 50 and 74 years and were free of dementia. Cognitive performance was assessed with a neuropsychological battery and cognitive impairment was defined as global cognitive z-score below 2 standard deviations. Variables used as input to the prediction models included demographics, social determinants, clinical conditions, family history, lifestyle, and laboratory tests. We developed machine learning models using logistic regression, neural networks, and gradient boosted trees. Participants’ mean age was 58.3±6.2 years, 55% were female. Cognitive impairment was present in 328 individuals (4%). Machine learning algorithms presented fair to good discrimination (areas under the ROC curve between 0.801 and 0.873). Extreme Gradient Boosting presented the highest discrimination, high specificity (97%), and negative predictive value (97%). Seventy-six percent of the individuals with cognitive impairment were included among the highest ranked individuals by this algorithm. In conclusion, we developed and tested a machine learning model to predict cognitive impairment based on primary care data that presented good discrimination and high specificity. These characteristics could support the detection of patients who would not benefit from cognitive assessment, facilitating the allocation of human and economic resources.en
dc.formatDigital
dc.format.extent8 p.
dc.identifier.doi10.1590/1414-431X2023e12475
dc.identifier.issn1414-431X
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/7226
dc.language.isoInglês
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.subjectArtificial intelligenceen
dc.subjectCognitionen
dc.subjectPredictionen
dc.subjectPrimary careen
dc.titleData-driven decision making for the screening of cognitive impairment in primary care: a machine learning approach using data from the ELSA-Brasil study
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://www.scielo.br/j/bjmbr/a/r9zmCWchBzPTmZTGMC8qwpR/?lang=en
local.publisher.countryNão Informado
local.subject.cnpqCIENCIAS DA SAUDE::MEDICINA
local.subject.cnpqCIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA
local.subject.cnpqCIENCIAS EXATAS E DA TERRA::CIENCIA DA COMPUTACAO
local.subject.cnpqCIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::NEUROLOGIA
local.typeArtigo Científico
publicationvolume.volumeNumber56
relation.isAuthorOfPublicationb10d272e-98b2-4953-8e51-37aea3fde20c
relation.isAuthorOfPublication.latestForDiscoveryb10d272e-98b2-4953-8e51-37aea3fde20c
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