An overview of cancer/testis antigens expression in classical Hodgkin's lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patients

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dc.contributor.authorInaoka, Riguel J
dc.contributor.authorJungbluth, Achim A
dc.contributor.authorBaiocchi, Otávio CG
dc.contributor.authorAssis, Mariane CG
dc.contributor.authorHanson, Nicole C
dc.contributor.authorFrosina, Denise
dc.contributor.authorTassello, Jodie
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorAlves, Antonio C
dc.contributor.authorColleoni, Gisele WB
dc.coverage.paisNão Informadopt_BR
dc.creatorInaoka, Riguel J
dc.creatorJungbluth, Achim A
dc.creatorBaiocchi, Otávio CG
dc.creatorAssis, Mariane CG
dc.creatorHanson, Nicole C
dc.creatorFrosina, Denise
dc.creatorTassello, Jodie
dc.creatorAlves, Antonio C
dc.creatorColleoni, Gisele WB
dc.date.accessioned2022-10-08T16:47:04Z
dc.date.available2022-10-08T16:47:04Z
dc.date.issued2011
dc.description.otherBackground Cancer/testis antigens are considered potential targets for immunotherapy due to their tumor-associated expression pattern. Although recent studies have demonstrated high expression of CT45 in classical Hodgkin's lymphomas (cHL), less is known about the expression pattern of other families of CTAs in cHL. We aim to evaluate the expression of MAGE-A family, MAGE-C1/CT7, MAGE-C2/CT10, NY-ESO1 and GAGE family in cHL and to correlate their expression with clinical and prognostic factors in cHL. Methods Tissue microarray was generated from 38 cHL archival cases from Pathology Department of Universidade Federal de Sao Paulo. Immunohistochemistry (IHC) was done using the following panel of antibodies: MAGE-A family (MA454, M3H67, 57B and 6C1), GAGE (#26), NY-ESO-1 (E978), MAGE-C1/CT7 (CT7-33) and MAGE-C2/CT10 (CT10#5). Results We found CTA expression in 21.1% of our cHL series. Among the tested CTAs, only MAGE-A family 7/38 (18.4%) and MAGE-C1/CT7 5/38 (13.2%) were positive in our cHL samples. We found higher CTA positivity in advanced stage (28.6%) compared to early stage (11.8%) disease, but this difference was not statistically significant. Analysis of other clinicopathological subgroups of cHL including histological subtypes, EBV status and response to treatment also did not demonstrate statistical significant differences in CTA expression. Conclusion We found CTA expression in 21.1% of cHL samples using our panel. Our preliminary findings suggest that from all CTAs included in this study, MAGE-A family and MAGE-C1/CT7 are the most interesting ones to be explored in further studies.pt_BR
dc.format.extent416pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doi10.1186/1471-2407-11-416pt_BR
dc.identifier.issn1471-2407pt_BR
dc.identifier.issue1pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/4209
dc.identifier.volume11pt_BR
dc.language.isoInglêspt_BR
dc.publisherSpringerpt_BR
dc.relation.ispartofBMC Cancerpt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITOR;pt_BR
dc.subject.keywordsHodgkinpt_BR
dc.subject.keywordsLymphomapt_BR
dc.subject.keywordscancer/testis antigenpt_BR
dc.subject.otherClínica médicapt_BR
dc.titleAn overview of cancer/testis antigens expression in classical Hodgkin's lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patientspt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://pubmed.ncbi.nlm.nih.gov/21951388/
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d
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