Clinical and laboratory profile of juvenile-onset systemic sclerosis in a Brazilian cohort

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dc.contributor.authorSampaio-Barros, Percival D
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorDel Rio, Ana Paula T
dc.contributor.authorLuppino-Assad, Ana Paula
dc.contributor.authorAndrade, Danieli CO
dc.contributor.authorMarques-Neto, João Francisco
dc.coverage.paisNão Informadopt_BR
dc.creatorSampaio-Barros, Percival D
dc.creatorDel Rio, Ana Paula T
dc.creatorLuppino-Assad, Ana Paula
dc.creatorAndrade, Danieli CO
dc.creatorMarques-Neto, João Francisco
dc.date.accessioned2022-08-08T18:32:08Z
dc.date.available2022-08-08T18:32:08Z
dc.date.issued2019
dc.description.otherObjective: To characterize the clinical and laboratory profile of juvenile-onset compared to adult-onset systemic sclerosis in a large Brazilian cohort.Methods: Retrospective analysis of a cohort of 1016 systemic sclerosis patients followed at the Scleroderma Outpatient Clinic from two referral university centers in Brazil. Patients were classified as systemic sclerosis according to the 1980 American College of Rhaumatology (ACR) criteria. Juvenile-onset systemic sclerosis was defined if age at onset was <16 years.Results: Thirty-one (3.1%) patients were classified as juvenile-onset systemic sclerosis. These patients were predominantly females (90.3%), Caucasians (71.0%), and presented diffuse systemic sclerosis (51.6%), with mean age at onset of 12.71 years. Compared to the adult-onset patients, juvenile onset was associated with diffuse systemic sclerosis (p < 0.001), calcinosis (p < 0.001), myositis (p = 0.050), and lower frequency of interstitial lung disease (p = 0.050), pulmonary hypertension (p = 0.035), and esophageal (p = 0.005) involvement.Conclusion: Juvenile-onset systemic sclerosis characterized a distinct clinical pattern in this large series of systemic sclerosis patients, since it was predominantly associated with diffuse systemic sclerosis without significant organ involvement.pt_BR
dc.format.extent43 –48pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doiDOI: 10.1177/2397198318769796pt_BR
dc.identifier.issue1pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/3912
dc.identifier.volume4pt_BR
dc.language.isoInglêspt_BR
dc.publisherSAGEpt_BR
dc.relation.ispartofJournal of Scleroderma and Related Disorderspt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITORpt_BR
dc.subject.keywordsSystemic sclerosispt_BR
dc.subject.keywordsepidemiologypt_BR
dc.subject.keywordsage at onsetpt_BR
dc.titleClinical and laboratory profile of juvenile-onset systemic sclerosis in a Brazilian cohortpt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://journals.sagepub.com/doi/full/10.1177/2397198318769796
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d
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