A Software to Compare Clusters between Groups and Its Application to the Study of Autism Spectrum Disorder

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dc.contributor.authorMACIEL CALEBE VIDAL
dc.contributor.authorSato, João R.
dc.contributor.authorBalardin, Joana B.
dc.contributor.authorTakahashi, Daniel Y.
dc.contributor.authorFujita, André
dc.creatorSato, João R.
dc.creatorBalardin, Joana B.
dc.creatorTakahashi, Daniel Y.
dc.creatorFujita, André
dc.date.accessioned2024-11-13T17:35:18Z
dc.date.available2024-11-13T17:35:18Z
dc.date.issued2017
dc.description.abstractUnderstanding how brain activities cluster can help in the diagnosis of neuropsychological disorders. Thus, it is important to be able to identify alterations in the clustering structure of functional brain networks. Here, we provide an R implementation of Analysis of Cluster Variability (ANOCVA), which statistically tests (1) whether a set of brain regions of interest (ROI) are equally clustered between two or more populations and (2) whether the contribution of each ROI to the differences in clustering is significant. To illustrate the usefulness of our method and software, we apply the R package in a large functional magnetic resonance imaging (fMRI) dataset composed of 896 individuals (529 controls and 285 diagnosed with ASD—autism spectrum disorder) collected by the ABIDE (The Autism Brain Imaging Data Exchange) Consortium. Our analysis show that the clustering structure of controls and ASD subjects are different (p < 0.001) and that specific brain regions distributed in the frontotemporal, sensorimotor, visual, cerebellar, and brainstem systems significantly contributed (p < 0.05) to this differential clustering. These findings suggest an atypical organization of domain-specific functionbrain modules in ASD.en
dc.formatDigital
dc.format.extent8 p.
dc.identifier.doi10.3389/fnins.2017.00016
dc.identifier.issn1662-453X
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/7219
dc.language.isoInglês
dc.relation.ispartofFrontiers in Neuroscience
dc.subjectAnalysis of Cluster Variabilityen
dc.subjectShouette statisticen
dc.subjectFunctional brain networken
dc.subjectABIDEen
dc.subjectfMRIen
dc.titleA Software to Compare Clusters between Groups and Its Application to the Study of Autism Spectrum Disorder
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2017.00016/full
local.publisher.countryNão Informado
local.subject.cnpqCIENCIAS DA SAUDE::MEDICINA::PSIQUIATRIA
local.subject.cnpqCIENCIAS BIOLOGICAS::BIOQUIMICA::BIOLOGIA MOLECULAR
local.subject.cnpqCIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA
local.subject.cnpqCIENCIAS EXATAS E DA TERRA::CIENCIA DA COMPUTACAO
local.typeArtigo Científico
publicationvolume.volumeNumber11
relation.isAuthorOfPublication3c34d0f1-1f7d-4405-a994-3484d365cebf
relation.isAuthorOfPublication.latestForDiscovery3c34d0f1-1f7d-4405-a994-3484d365cebf
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