Effect of age at disease onset in the clinical profile of spondyloarthritis: a study of 1424 Brazilian patients

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dc.contributor.authorSkare, T. L.
dc.contributor.authorLeite, N.
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorGonçalves, C R
dc.contributor.authorSilva, J A B da
dc.contributor.authorXimenes, A C
dc.contributor.authorBértolo, M B
dc.contributor.authorRibeiro, S L E
dc.contributor.authorKeiserman, M
dc.contributor.authorMenin, R
dc.contributor.authorCarneiro, S
dc.contributor.authorAzevedo, V F
dc.contributor.authorVieira, W P
dc.contributor.authorAlbuquerque, E das N
dc.contributor.authorBianchi, W A
dc.contributor.authorBonfiglioli, R
dc.contributor.authorCampanholo, C
dc.contributor.authorCarvalho, H M S
dc.contributor.authorCosta, I P
dc.contributor.authorDuarte, A P
dc.contributor.authorGavi, M B O
dc.contributor.authorKohem, C L
dc.contributor.authorLima, S A L
dc.contributor.authorMeirelles, E S
dc.contributor.authorPereira, I A
dc.contributor.authorPinheiro, M M
dc.contributor.authorPolito, E
dc.contributor.authorResende, G G
dc.contributor.authorRocha, F A C
dc.contributor.authorSantiago, M B
dc.contributor.authorSauma, M de F L C
dc.contributor.authorSampaio-Barros, P D
dc.coverage.paisNão Informadopt_BR
dc.creatorSkare, T. L.
dc.creatorLeite, N.
dc.creatorGonçalves, C R
dc.creatorSilva, J A B da
dc.creatorXimenes, A C
dc.creatorBértolo, M B
dc.creatorRibeiro, S L E
dc.creatorKeiserman, M
dc.creatorMenin, R
dc.creatorCarneiro, S
dc.creatorAzevedo, V F
dc.creatorVieira, W P
dc.creatorAlbuquerque, E das N
dc.creatorBianchi, W A
dc.creatorBonfiglioli, R
dc.creatorCampanholo, C
dc.creatorCarvalho, H M S
dc.creatorCosta, I P
dc.creatorDuarte, A P
dc.creatorGavi, M B O
dc.creatorKohem, C L
dc.creatorLima, S A L
dc.creatorMeirelles, E S
dc.creatorPereira, I A
dc.creatorPinheiro, M M
dc.creatorPolito, E
dc.creatorResende, G G
dc.creatorRocha, F A C
dc.creatorSantiago, M B
dc.creatorSauma, M de F L C
dc.creatorSampaio-Barros, P D
dc.date.accessioned2022-10-08T14:37:10Z
dc.date.available2022-10-08T14:37:10Z
dc.date.issued2012
dc.description.otherObjectives: To analyse demographic and clinical variables in patients with disease onset before and after 40, 45 and 50 years in a large series of Brazilian SpA patients. Methods: A common protocol of investigation was prospectively applied to 1424 SpA patients in 29 centres distributed through the main geographical regions in Brazil. The mean age at disease onset was 28.56 ± 12.34 years, with 259 patients (18.2%) referring disease onset after 40 years, 151 (10.6%) after 45 years and 81 (5.8%) after 50 years. Clinical and demographic variables and disease indices (BASDAI, BASFI, BASRI, MASES, ASQoL) were investigated. Ankylosing spondylitis was the most frequent disease (66.3%), followed by psoriatic arthritis (18%), undifferentiated SpA (6.7%), reactive arthritis (5.5%), and enteropathic arthritis (3.5%). Results: Comparing the groups according to age of disease onset, those patients with later onset presented statistical association with female gender, peripheral arthritis, dactylitis, nail involvement and psoriasis, as well as negative statistical association with inflammatory low back pain, alternating buttock pain, radiographic sacroiliitis, hip involvement, positive familial history, HLA-B27 and uveitis. BASDAI, BASFI and quality of life, as well as physicians and patient's global assessment, were similar in all the groups. Radiographic indices showed worse results in the younger age groups. Conclusions: There are two different clinical patterns in SpA defined by age at disease onset: one with predominance of axial symptoms in the group with disease onset ≤ 40 years and another favouring the peripheral manifestations in those with later disease onset.pt_BR
dc.format.extent351 - 357pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.issn1593-098Xpt_BR
dc.identifier.issn0392-856Xpt_BR
dc.identifier.issue3pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/4201
dc.identifier.volume30pt_BR
dc.language.isoInglêspt_BR
dc.publisherClinical and Experimental Rheumatologypt_BR
dc.relation.ispartofClinical and Experimental Rheumatologypt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITOR;pt_BR
dc.subject.keywordsspondyloarthritispt_BR
dc.subject.keywordsankylosing spondylitispt_BR
dc.subject.keywordsage at onsetpt_BR
dc.subject.keywordsoutcomept_BR
dc.subject.otherClínica médicapt_BR
dc.titleEffect of age at disease onset in the clinical profile of spondyloarthritis: a study of 1424 Brazilian patientspt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://pubmed.ncbi.nlm.nih.gov/22510473/
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d
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