Cancer/testis antigens expression and autologous serological response in a set of Brazilian non-Hodgkin’s lymphoma patients

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dc.contributor.authorInaoka, Riguel J.
dc.contributor.authorJungbluth, Achim A.
dc.contributor.authorGnjatic, Sacha
dc.contributor.authorRitter, Erika
dc.contributor.authorHanson, Nicole C.
dc.contributor.authorFrosina, Denise
dc.contributor.authorTassello, Jodie
dc.contributor.authorEtto, Leina Y.
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorAlves, Antonio C.
dc.contributor.authorColleoni, Gisele W. B.
dc.coverage.paisAlemanhapt_BR
dc.creatorInaoka, Riguel J.
dc.creatorJungbluth, Achim A.
dc.creatorGnjatic, Sacha
dc.creatorRitter, Erika
dc.creatorHanson, Nicole C.
dc.creatorFrosina, Denise
dc.creatorTassello, Jodie
dc.creatorEtto, Leina Y.
dc.creatorAlves, Antonio C.
dc.creatorColleoni, Gisele W. B.
dc.date.accessioned2022-10-08T12:53:25Z
dc.date.available2022-10-08T12:53:25Z
dc.date.issued2012
dc.description.otherBackground Based on their tumor-associated expression pattern, cancer/testis antigens (CTAs) are considered potential targets for cancer immunotherapy. We aim to evaluate the expression of CTAs in non-Hodgkin’s lymphoma (NHL) samples and the ability of these patients to elicit spontaneous humoral immune response against CTAs. Methods Expression of MAGE-A family, CT7/MAGE-C1, CT10/MAGE-C2, GAGE and NY-ESO-1 was analyzed by immunohistochemistry in a tissue microarray generated from 106 NHL archival cases. The humoral response against 19 CTAs was tested in 97 untreated NHL serum samples using ELISA technique. Results 11.3 % of NHL tumor samples expressed at least 1 CTA. MAGE-A family (6.6 %), GAGE (5.7 %) and NY-ESO-1(4.7 %) were the most frequently expressed antigens. We found no statistically significant correlation between CTA positivity and clinical parameters such as NHL histological subtype, Ann Arbor stage, international prognostic index score, response to treatment and overall survival. Humoral response against at least 1 CTA was observed in 16.5 % of NHL serum samples. However, overall seroreactivity was low, and strong titers (>1:1000) were observed in only two diffuse large B-cell lymphomas patients against CT45. Conclusion Our findings are in agreement with most of published studies in this field to date and suggest an overall low expression of CTAs in NHL patients. However, as many new CTAs have been described recently and some of them are found to be highly expressed in NHL cell lines and tumor samples, further studies exploring the expression of different panels of CTAs are needed to evaluate their role as candidates for immunotherapy in NHL patients.pt_BR
dc.format.extent2207 – 2214pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doihttps://doi.org/10.1007/s00262-012-1285-6pt_BR
dc.identifier.issn1432-0851pt_BR
dc.identifier.issn0340-7004pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/4198
dc.identifier.volume61pt_BR
dc.language.isoInglêspt_BR
dc.publisherSpringerpt_BR
dc.relation.ispartofCancer Immunology, Immunotherapypt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITOR;pt_BR
dc.subject.keywordsNon-Hodgkin’s lymphomapt_BR
dc.subject.keywordsCancer/testis antigenspt_BR
dc.subject.keywordsHumoral responsept_BR
dc.subject.otherClínica médicapt_BR
dc.titleCancer/testis antigens expression and autologous serological response in a set of Brazilian non-Hodgkin’s lymphoma patientspt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://link.springer.com/article/10.1007/s00262-012-1285-6
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d
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