Cognitive performance in depressed patients after chronic use of antidepressants

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dc.contributor.authorRINALDO ARTES
dc.contributor.authorGorenstein, Clarice
dc.contributor.authorCarvalho, Stefania Caldeira de
dc.contributor.authorMoreno, Ricardo Alberto
dc.contributor.authorMarcourakis, Tania
dc.coverage.cidadeBerlimpt_BR
dc.coverage.paisAlemanhapt_BR
dc.creatorGorenstein, Clarice
dc.creatorCarvalho, Stefania Caldeira de
dc.creatorMoreno, Ricardo Alberto
dc.creatorMarcourakis, Tania
dc.date.accessioned2022-08-18T14:23:01Z
dc.date.available2022-08-18T14:23:01Z
dc.date.issued2006
dc.description.notesTexto completopt_BR
dc.description.otherRationale: Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. Objectives: This study evaluated the cognitive performance of depressed patients treated with antidepressants for at least 6 months. Methods: Patients with major depression (DSM-IV) using imipramine for 2.4+/-0.6 years (mean+/-SE), clomipramine for 2.8+/-1.2 years, fluoxetine for 1.8+/-0.3 years and sertraline for 1.5+/-0.3 years were compared to matched controls (sex, age and educational level) without any psychiatric diagnosis. Memory evaluation consisted of episodic, implicit and working memory tests as well as metamemory assessment. Results: (a) Psychomotor performance of patients taking imipramine was worse than that of controls in inserting pins and a visual reaction time task; on the performance of tapping the difference from controls varied according to dose/weight for patients taking clomipramine and fluoxetine. (b) For memory tests, differences between patients taking sertraline and controls were observed in the number of digits and words recalled; the difference between patients and controls varied according to dose/weight on the number of familiar words correctly completed for patients taking clomipramine and on digit span backward for those taking sertraline. (c) Metamemory was worse in all patient groups irrespective of patients' clinical state. Conclusions: The impairment in psychomotor and memory performances associated with these antidepressants seems to be of low intensity and of questionable clinical relevance.pt_BR
dc.format.extentp. 84-92pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doihttps://doi.org/10.1007/s00213-005-0274-2pt_BR
dc.identifier.issn00333158pt_BR
dc.identifier.issn14322072pt_BR
dc.identifier.issue1pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/4038
dc.identifier.volume185pt_BR
dc.language.isoInglêspt_BR
dc.publisherSpringerpt_BR
dc.relation.ispartofPsychopharmacologypt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITORpt_BR
dc.subject.keywordsclomipraminept_BR
dc.subject.keywordsimipraminept_BR
dc.subject.keywordsfluxetinept_BR
dc.subject.keywordssertralinept_BR
dc.subject.keywordsdepressive disorderpt_BR
dc.subject.keywordscognitionpt_BR
dc.titleCognitive performance in depressed patients after chronic use of antidepressantspt_BR
dc.typejournal article
dspace.entity.typePublication
local.subject.cnpqCiências Biológicaspt_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublication8b791c94-f3e5-4e04-af26-594195a8f576
relation.isAuthorOfPublication.latestForDiscovery8b791c94-f3e5-4e04-af26-594195a8f576

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