Identification of alterations associated with age in the clustering structure of functional brain networks

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dc.contributor.authorGuzman, Grover E. C.
dc.contributor.authorSato, Joao R.
dc.contributor.authorMACIEL CALEBE VIDAL
dc.contributor.authorFujita, Andre
dc.creatorGuzman, Grover E. C.
dc.creatorSato, Joao R.
dc.creatorFujita, Andre
dc.date.accessioned2024-11-12T20:53:53Z
dc.date.available2024-11-12T20:53:53Z
dc.date.issued2018
dc.description.abstractInitial studies using resting-state functional magnetic resonance imaging on the trajectories of the brain network from childhood to adulthood found evidence of functional integration and segregation over time. The comprehension of how healthy individuals’ functional integration and segregation occur is crucial to enhance our understanding of possible deviations that may lead to brain disorders. Recent approaches have focused on the framework wherein the functional brain network is organized into spatially distributed modules that have been associated with specific cognitive functions. Here, we tested the hypothesis that the clustering structure of brain networks evolves during development. To address this hypothesis, we defined a measure of how well a brain region is clustered (network fitness index), and developed a method to evaluate its association with age. Then, we applied this method to a functional magnetic resonance imaging data set composed of 397 males under 31 years of age collected as part of the Autism Brain Imaging Data Exchange Consortium. As results, we identified two brain regions for which the clustering change over time, namely, the left middle temporal gyrus and the left putamen. Since the network fitness index is associated with both integration and segregation, our finding suggests that the identified brain region plays a role in the development of brain systems.en
dc.formatDigital
dc.format.extent14 p.
dc.identifier.doi10.1371/journal.pone.0195906
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/7218
dc.language.isoInglês
dc.relation.ispartofPLOS ONE
dc.titleIdentification of alterations associated with age in the clustering structure of functional brain networks
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195906
local.publisher.countryNão Informado
local.subject.cnpqCIENCIAS DA SAUDE
local.subject.cnpqCIENCIAS DA SAUDE::MEDICINA::RADIOLOGIA MEDICA
local.subject.cnpqCIENCIAS BIOLOGICAS
local.subject.cnpqCIENCIAS EXATAS E DA TERRA::MATEMATICA::MATEMATICA APLICADA
local.subject.cnpqCIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA::ESTATISTICA
local.subject.cnpqENGENHARIAS::ENGENHARIA BIOMEDICA
local.typeArtigo Científico
relation.isAuthorOfPublication3c34d0f1-1f7d-4405-a994-3484d365cebf
relation.isAuthorOfPublication.latestForDiscovery3c34d0f1-1f7d-4405-a994-3484d365cebf
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