Angiomirs expression profiling in diffuse large B-Cell lymphoma

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dc.contributor.authorBorges, Natália M
dc.contributor.authorElias, Marcela do Vale
dc.contributor.authorFook-Alves, Veruska L
dc.contributor.authorAndrade, Tathiana A
dc.contributor.authorConti, Marina Lourenço de
dc.contributor.authorMacedo, Mariana Petaccia
dc.contributor.authorBegnami, Maria Dirlei
dc.contributor.authorCampos, Antônio Hugo J F M
dc.contributor.authorEtto, Leina Yukari
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorAlves, Antonio C
dc.contributor.authorYoung, Ken H
dc.contributor.authorColleoni, Gisele W B
dc.coverage.paisNão Informadopt_BR
dc.creatorBorges, Natália M
dc.creatorElias, Marcela do Vale
dc.creatorFook-Alves, Veruska L
dc.creatorAndrade, Tathiana A
dc.creatorConti, Marina Lourenço de
dc.creatorMacedo, Mariana Petaccia
dc.creatorBegnami, Maria Dirlei
dc.creatorCampos, Antônio Hugo J F M
dc.creatorEtto, Leina Yukari
dc.creatorAlves, Antonio C
dc.creatorYoung, Ken H
dc.creatorColleoni, Gisele W B
dc.date.accessioned2022-08-10T21:12:10Z
dc.date.available2022-08-10T21:12:10Z
dc.date.issued2016
dc.description.otherDespite advances in treatment, 30% of diffuse large B-cell lymphoma (DLBCL) cases are refractory or relapse after chemoimmunotherapy. Currently, the relationship between angiogenesis and angiomiRs in DLBCL is unknown. We classified 84 DLBCL cases according to stromal signatures and evaluated the expression of pro- and antiangiomiRs in paraffin embedded tissues of DLBCL and correlated them with microvascular density (MVD). 40% of cases were classified as stromal-1, 50% as stromal-2 and 10% were not classified. We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378 in 14%, 57%, 30%, 45%, 12%, 12%, 56%, 58% and 48% of the cases, respectively. Among antiangiomiRs we found decreased expression of miR-16, miR-20b, miR-92a, miR-221 and miR-328 in, respectively, 27%, 71%, 2%, 44% and 11%. We found association between increased expression of proangiomiRs miR-126 and miR-130a and antiangiomiR miR-328 and the subtype non-GCB. We found higher levels of the antiangiomiRs miR-16, miR-221 and miR-328 in patients with low MVD and stromal-1 signature. IPI and CD34 confirmed independent impact on survival of the study group. None of the above angiomiRs showed significance as biomarker in an independent serum samples cohort of patients and controls. In conclusion, we confirmed association between antiangiomiRs miR-16, miR-221 and miR-328 and stromal-1 signature. Four angiomiRs emerged as potential therapeutic targets: proangiomiRs miR-17, miR-210 and miR-296 and antiangiomiR miR-20b. Although the four microRNAs seem to be important in DLBCL pathogenesis, they were not predictive of DLBCL onset or relapse in the serum independent cohort.pt_BR
dc.format.extentp. 4806-4816pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doi10.18632/oncotarget.6624pt_BR
dc.identifier.issn1949-2553pt_BR
dc.identifier.issue4pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/3945
dc.identifier.volume7pt_BR
dc.language.isoInglêspt_BR
dc.publisherImpact Journalspt_BR
dc.relation.ispartofOncotargetpt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITORpt_BR
dc.subject.keywordsangiogenesispt_BR
dc.subject.keywordslymphomapt_BR
dc.subject.keywordsmicroRNAspt_BR
dc.titleAngiomirs expression profiling in diffuse large B-Cell lymphomapt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://www.oncotarget.com/archive/v7/i4/
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d

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