Long non-coding RNAs associated with infection and vaccine-induced immunity

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dc.contributor.authorLüscher-Dias, Thomaz
dc.contributor.authorConceição, Izabela Mamede
dc.contributor.authorSchuch, Viviane
dc.contributor.authorMaracaja-Coutinho, Vinicius
dc.contributor.authorPAULO DE PAIVA ROSA AMARAL
dc.coverage.paisNão Informadopt_BR
dc.creatorLüscher-Dias, Thomaz
dc.creatorConceição, Izabela Mamede
dc.creatorSchuch, Viviane
dc.creatorMaracaja-Coutinho, Vinicius
dc.date.accessioned2022-12-10T17:55:57Z
dc.date.available2022-12-10T17:55:57Z
dc.date.issued2021
dc.description.notesTexto completopt_BR
dc.description.otherThe immune system responds to infection or vaccination through a dynamic and complex process that involves several molecular and cellular factors. Among these factors, long non-coding RNAs (lncRNAs) have emerged as significant players in all areas of biology, particularly in immunology. Most of the mammalian genome is transcribed in a highly reg ulated manner, generating a diversity of lncRNAs that impact the differentiation and activa tion of immune cells and affect innate and adaptive immunity. Here, we have reviewed the range of functions and mechanisms of lncRNAs in response to infectious disease, including pathogen recognition, interferon (IFN) response, and inflammation. We describe examples of lncRNAs exploited by pathogenic agents during infection, which indicate that lncRNAs are a fundamental part of the arms race between hosts and pathogens. We also discuss lncRNAs potentially implicated in vaccine-induced immunity and present examples of lncR NAs associated with the antibody response of subjects receiving Influenza or Yellow Fever vaccines. Elucidating the widespread involvement of lncRNAs in the immune system will im prove our understanding of the factors affecting immune response to different pathogenic agents, to better prevent and treat disease.pt_BR
dc.format.extentp. 657–669pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doi10.1042/EBC20200072pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/4883
dc.identifier.volume65pt_BR
dc.language.isoInglêspt_BR
dc.publisherPortland Press Limitedpt_BR
dc.relation.ispartofEssays in Biochemistrypt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITORpt_BR
dc.titleLong non-coding RNAs associated with infection and vaccine-induced immunitypt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://doi.org/10.1042/EBC20200072
local.subject.cnpqCiências Biológicaspt_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublication90769ac2-5975-4a9d-8316-ee9653a944bd
relation.isAuthorOfPublication.latestForDiscovery90769ac2-5975-4a9d-8316-ee9653a944bd
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