Ethnic Influence in Clinical and Functional Measures of Brazilian Patients with Spondyloarthritis

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dc.contributor.authorSkare, Thelma L.
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorGonçalves, Célio R.
dc.contributor.authorSilva, José Antonio Braga Da
dc.contributor.authorXimenes, Antonio Carlos
dc.contributor.authorBértolo, Manoel B.
dc.contributor.authorRibeiro, Sandra L.E.
dc.contributor.authorKeiserman, Mauro
dc.contributor.authorMenin, Rita
dc.contributor.authorCarneiro, Sueli
dc.contributor.authorAzevedo, Valderílio F.
dc.contributor.authorVieira, Walber P.
dc.contributor.authorAlbuquerque, Elisa N.
dc.contributor.authorBianchi, Washington A.
dc.contributor.authorBonfiglioli, Rubens
dc.contributor.authorCampanholo, Cristiano
dc.contributor.authorCarvalho, Hellen M.S.
dc.contributor.authorCosta, Izaias P.
dc.contributor.authorDuarte, Angela P.
dc.contributor.authorGavi, Maria Bernadete O.
dc.contributor.authorKohem, Charles L.
dc.contributor.authorLeite, Nocy H.
dc.contributor.authorLima, Sonia A.L.
dc.contributor.authorMeirelles, Eduardo S.
dc.contributor.authorPereira, Ivânio A.
dc.contributor.authorPinheiro, Marcelo M.
dc.contributor.authorPolito, Elizandra
dc.contributor.authorResende, Gustavo G.
dc.contributor.authorRocha, Francisco Airton C.
dc.contributor.authorSantiago, Mittermayer B.
dc.contributor.authorSauma, Maria De Fátima L.C.
dc.contributor.authorSampaio-Barros, Percival D.
dc.coverage.paisCanadápt_BR
dc.creatorSkare, Thelma L.
dc.creatorGonçalves, Célio R.
dc.creatorSilva, José Antonio Braga Da
dc.creatorXimenes, Antonio Carlos
dc.creatorBértolo, Manoel B.
dc.creatorRibeiro, Sandra L.E.
dc.creatorKeiserman, Mauro
dc.creatorMenin, Rita
dc.creatorCarneiro, Sueli
dc.creatorAzevedo, Valderílio F.
dc.creatorVieira, Walber P.
dc.creatorAlbuquerque, Elisa N.
dc.creatorBianchi, Washington A.
dc.creatorBonfiglioli, Rubens
dc.creatorCampanholo, Cristiano
dc.creatorCarvalho, Hellen M.S.
dc.creatorCosta, Izaias P.
dc.creatorDuarte, Angela P.
dc.creatorGavi, Maria Bernadete O.
dc.creatorKohem, Charles L.
dc.creatorLeite, Nocy H.
dc.creatorLima, Sonia A.L.
dc.creatorMeirelles, Eduardo S.
dc.creatorPereira, Ivânio A.
dc.creatorPinheiro, Marcelo M.
dc.creatorPolito, Elizandra
dc.creatorResende, Gustavo G.
dc.creatorRocha, Francisco Airton C.
dc.creatorSantiago, Mittermayer B.
dc.creatorSauma, Maria De Fátima L.C.
dc.creatorSampaio-Barros, Percival D.
dc.date.accessioned2022-10-08T14:58:26Z
dc.date.available2022-10-08T14:58:26Z
dc.date.issued2012
dc.description.otherObjective. Spondyloarthritides (SpA) can present different disease spectra according to ethnic background. The Brazilian Registry of Spondyloarthritis (RBE) is a nationwide registry that comprises a large databank on clinical, functional, and treatment data on Brazilian patients with SpA. The aim of our study was to analyze the influence of ethnic background in SpA disease patterns in a large series of Brazilian patients. Methods. A common protocol of investigation was prospectively applied to 1318 SpA patients in 29 centers distributed through the main geographical regions in Brazil. The group comprised whites (65%), African Brazilians (31.3%), and people of mixed origins (3.7%). Clinical and demographic variables and various disease index scores were compiled. Ankylosing spondylitis (AS) was the most frequent disease in the group (65.1%); others were psoriatic arthritis (18.3%), undifferentiated SpA (6.8%), enteropathic arthritis (3.7%), and reactive arthritis (3.4%). Results. White patients were significantly associated with psoriasis (p = 0.002), positive HLA-B27 (p = 0.014), and use of corticosteroids (p < 0.0001). Hip involvement (p = 0.02), axial inflammatory pain (p = 0.04), and radiographic sacroiliitis (p = 0.025) were associated with African Brazilian descent. Sex distribution, family history, and presence of peripheral arthritis, uveitis, dactylitis, urethritis, and inflammatory bowel disease were similar in the 3 groups, as well as age at disease onset, time from first symptom until diagnosis, and use of anti-tumor necrosis factor-α agents (p > 0.05). Schober test and thoracic expansion were similar in the 3 groups, whereas African Brazilians had higher Maastricht Ankylosing Spondylitis Enthesitis Scores (p = 0.005) and decreased lateral lumbar flexion (p = 0.003), while whites had a higher occiput-to-wall distance (p = 0.02). African Brazilians reported a worse patient global assessment of disease (p = 0.011). Other index scores and prevalence of work incapacity were similar in the 3 groups, although African Brazilians had worse performance in the Ankylosing Spondylitis Quality of Life questionnaire (p < 0.001). Conclusion. Ethnic background is associated with distinct clinical aspects of SpA in Brazilian patients. African Brazilian patients with SpA have a poorer quality of life and report worse disease compared to whites.pt_BR
dc.format.extent141 - 147pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doiDOI: https://doi.org/10.3899/jrheum.110372pt_BR
dc.identifier.issn0315-162Xpt_BR
dc.identifier.issn1499-2752pt_BR
dc.identifier.issue1pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/4203
dc.identifier.volume39pt_BR
dc.language.isoInglêspt_BR
dc.publisherCanadian Rheumatology Associationpt_BR
dc.relation.ispartofThe Journal of Rheumatologypt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITOR;pt_BR
dc.subject.keywordsspondyloarthritispt_BR
dc.subject.keywordsethnic groupspt_BR
dc.subject.keywordsbrazilianpt_BR
dc.subject.keywordspopulationpt_BR
dc.subject.keywordsepidemiologypt_BR
dc.subject.otherClínica médicapt_BR
dc.titleEthnic Influence in Clinical and Functional Measures of Brazilian Patients with Spondyloarthritispt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://www.jrheum.org/content/39/1/141.short
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d
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