Development of a risk score for earlier diagnosis of chronic kidney disease in children

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dc.contributor.authorCRISTINE CAMPOS DE XAVIER PINTO
dc.contributor.authorNogueira, Paulo Cesar Koch
dc.contributor.authorKonstantyner, Tulio
dc.contributor.authorCarvalho, Maria Fernanda Camargo de
dc.contributor.authorPaz, Isabel de Pádua
dc.contributor.authorBelangero, Vera Maria Santoro
dc.contributor.authorTavares, Marcelo de Sousa
dc.contributor.authorGarcia, Clotilde Druck
dc.contributor.authorFerra Neto, Oreste Angelo
dc.contributor.authorZuntini, Káthia Liliane da Cunha Ribeiro
dc.contributor.authorLordelo, Marina da Rocha
dc.contributor.authorOi, Samira Shizuko Parreao
dc.contributor.authorDamasceno, Renata Trindade
dc.contributor.authorSesso, Ricardo
dc.coverage.cidadeSan Franciscopt_BR
dc.coverage.paisEstados Unidospt_BR
dc.creatorNogueira, Paulo Cesar Koch
dc.creatorKonstantyner, Tulio
dc.creatorCarvalho, Maria Fernanda Camargo de
dc.creatorPaz, Isabel de Pádua
dc.creatorBelangero, Vera Maria Santoro
dc.creatorTavares, Marcelo de Sousa
dc.creatorGarcia, Clotilde Druck
dc.creatorFerra Neto, Oreste Angelo
dc.creatorZuntini, Káthia Liliane da Cunha Ribeiro
dc.creatorLordelo, Marina da Rocha
dc.creatorOi, Samira Shizuko Parreao
dc.creatorDamasceno, Renata Trindade
dc.creatorSesso, Ricardo
dc.date.accessioned2022-12-19T01:34:36Z
dc.date.available2022-12-19T01:34:36Z
dc.date.issued2019
dc.description.notesTexto completopt_BR
dc.description.otherObjective: To develop a clinical score for the early identification of chronic kidney disease (CKD) in children and adolescents. The early diagnosis of CKD in childhood allows the adoption of measures to slow the progression of the disease, thereby reducing morbidity and mortality. Nevertheless, the diagnosis is often made too late for proper patient management. Study design: We preformed a case-control study of a multicenter Brazilian sample of 752 pediatric patients; the study cases (n = 376) were CKD patients with a median estimated GFR of 37 (IQR = 22 to 57) ml/min/1.73 m2. The control group (n = 376) comprised age-, gender- and center-matched children who were followed for nonrenal diseases. Potential risk factors were investigated through a standard questionnaire that included symptoms, medical history, and a clinical examination. Two multivariable models (A and B) were fitted to assess predictors of the diagnosis of CKD. Results: In model A, 9 variables were associated with CKD diagnosis: antenatal ultrasound with urinary malformation, recurrent urinary tract infection, polyuria, abnormal urine stream, nocturia, growth curve flattening, history of hypertension, foamy urine and edema (c-statistic = 0.938). Model B had the same variables as model A, except for the addition of the history of admission during the neonatal period and the exclusion of antenatal ultrasound variables (c-statistic = 0.927). Conclusions: The present scores may serve as a warning sign for CKD diagnosis in children among professionals working in the primary care setting where the symptoms associated with a risk of CKD may be overlooked.pt_BR
dc.format.extentp. 1-11pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0215100pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.issue4pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/5064
dc.identifier.volume19pt_BR
dc.language.isoInglêspt_BR
dc.publisherSan Francisco CA: Public Library of Sciencept_BR
dc.relation.ispartofPloS onept_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITORpt_BR
dc.titleDevelopment of a risk score for earlier diagnosis of chronic kidney disease in childrenpt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://pubmed.ncbi.nlm.nih.gov/31002677/
local.subject.cnpqCiências Sociais Aplicadaspt_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationfb10226e-e3f9-41af-9eab-3fd279ec531f
relation.isAuthorOfPublication.latestForDiscoveryfb10226e-e3f9-41af-9eab-3fd279ec531f
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