Survival, Causes of Death, and Prognostic Factors in Systemic Sclerosis: Analysis of 947 Brazilian Patients

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dc.contributor.authorSampaio-Barros, Percival D.
dc.contributor.authorADRIANA BRUSCATO BORTOLUZZO
dc.contributor.authorMarangoni, Roberta G.
dc.contributor.authorRocha, Luiza F.
dc.contributor.authorDel Rio, Ana Paula T.
dc.contributor.authorSamara, Adil M.
dc.contributor.authorYoshinari, Natalino H.
dc.contributor.authorMarques-Neto, João Francisco
dc.coverage.cidadeTorontopt_BR
dc.coverage.paisCanadápt_BR
dc.creatorSampaio-Barros, Percival D.
dc.creatorMarangoni, Roberta G.
dc.creatorRocha, Luiza F.
dc.creatorDel Rio, Ana Paula T.
dc.creatorSamara, Adil M.
dc.creatorYoshinari, Natalino H.
dc.creatorMarques-Neto, João Francisco
dc.date.accessioned2022-10-08T15:34:46Z
dc.date.available2022-10-08T15:34:46Z
dc.date.issued2012
dc.description.otherObjective. To analyze survival, prognostic factors, and causes of death in a large cohort of patients with systemic sclerosis (SSc). Methods. From 1991 to 2010, 947 patients with SSc were treated at 2 referral university centers in Brazil. Causes of death were considered SSc-related and non-SSc-related. Multiple logistic regression analysis was used to identify prognostic factors. Survival at 5 and 10 years was estimated using the Kaplan-Meier method. Results. One hundred sixty-eight patients died during the followup. Among the 110 deaths considered related to SSc, there was predominance of lung (48.1%) and heart (24.5%) involvement. Most of the 58 deaths not related to SSc were caused by infection, cardiovascular or cerebrovascular disease, and cancer. Male sex, modified Rodnan skin score (mRSS) > 20, osteoarticular involvement, lung involvement, and renal crisis were the main prognostic factors associated to death. Overall survival rate was 90% for 5 years and 84% for 10 years. Patients presented worse prognosis if they had diffuse SSc (85% vs 92% at 5 yrs, respectively, and 77% vs 87% at 10 yrs, compared to limited SSc), male sex (77% vs 90% at 5 yrs and 64% vs 86% at 10 yrs, compared to female sex), and mRSS > 20 (83% vs 90% at 5 yrs and 66% vs 86% at 10 yrs, compared to mRSS < 20). Conclusion. Survival was worse in male patients with diffuse SSc, and lung and heart involvement represented the main causes of death in this South American series of patients with SSc.pt_BR
dc.format.extent1971 - 1978pt_BR
dc.format.mediumDigitalpt_BR
dc.identifier.doihttps://doi.org/10.3899/jrheum.111582pt_BR
dc.identifier.issn0315-162Xpt_BR
dc.identifier.issue10pt_BR
dc.identifier.urihttps://repositorio.insper.edu.br/handle/11224/4206
dc.identifier.volume39pt_BR
dc.language.isoInglêspt_BR
dc.publisherCanadian Rheumatology Associationpt_BR
dc.relation.ispartofThe Journal of Rheumatologypt_BR
dc.rights.licenseO INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITOR;pt_BR
dc.subject.keywordssystemic sclerosispt_BR
dc.subject.keywordssurvival analysispt_BR
dc.subject.keywordsprognosispt_BR
dc.subject.keywordscauses of deathpt_BR
dc.subject.keywordslung involvementpt_BR
dc.subject.keywordsheart involvementpt_BR
dc.subject.otherClínica médicapt_BR
dc.titleSurvival, Causes of Death, and Prognostic Factors in Systemic Sclerosis: Analysis of 947 Brazilian Patientspt_BR
dc.typejournal article
dspace.entity.typePublication
local.identifier.sourceUrihttps://www.jrheum.org/content/39/10/1971.short
local.subject.cnpqCiências da Saúdept_BR
local.typeArtigo Científicopt_BR
relation.isAuthorOfPublicationccfd47d5-bd80-4464-98ce-629abb672e3d
relation.isAuthorOfPublication.latestForDiscoveryccfd47d5-bd80-4464-98ce-629abb672e3d

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