Please use this identifier to cite or link to this item: https://repositorio.insper.edu.br/handle/11224/3986
Type: Artigo Científico
Title: Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?
Author: Braga, Walter MT
Silva, Bruna R da
Alves, Veruska LF
Bortoluzzo, Adriana Bruscato
Atanackovic, Djordje
Colleoni, Gisele WB
Publication Date: 2014
Abstract: Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor‐infiltrating T cells. Materials & methods:MAGE‐C1/CT‐7, MAGEA3/6, NY‐ESO‐1, LAGE‐1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT‐PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results:MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4+ T‐cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4+ T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM
Keywords (english terms): cancer/testis antigen
multiple myeloma
Th17
Treg
Language: Inglês
CNPq Area: Ciências da Saúde
URI: https://www.futuremedicine.com/doi/epub/10.2217/imt.14.24
Copyright: O INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITOR
Notes: PRELIMINARY COMMUNICATION
Appears in Collections:Coleção de Artigos Científicos

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