Please use this identifier to cite or link to this item: https://repositorio.insper.edu.br/handle/11224/5064
Type: Artigo Científico
Title: Development of a risk score for earlier diagnosis of chronic kidney disease in children
Author: Pinto, Cristine Campos de Xavier
Nogueira, Paulo Cesar Koch
Konstantyner, Tulio
Carvalho, Maria Fernanda Camargo de
Paz, Isabel de Pádua
Belangero, Vera Maria Santoro
Tavares, Marcelo de Sousa
Garcia, Clotilde Druck
Ferra Neto, Oreste Angelo
Zuntini, Káthia Liliane da Cunha Ribeiro
Lordelo, Marina da Rocha
Oi, Samira Shizuko Parreao
Damasceno, Renata Trindade
Sesso, Ricardo
Publication Date: 2019
Abstract: Objective: To develop a clinical score for the early identification of chronic kidney disease (CKD) in children and adolescents. The early diagnosis of CKD in childhood allows the adoption of measures to slow the progression of the disease, thereby reducing morbidity and mortality. Nevertheless, the diagnosis is often made too late for proper patient management. Study design: We preformed a case-control study of a multicenter Brazilian sample of 752 pediatric patients; the study cases (n = 376) were CKD patients with a median estimated GFR of 37 (IQR = 22 to 57) ml/min/1.73 m2. The control group (n = 376) comprised age-, gender- and center-matched children who were followed for nonrenal diseases. Potential risk factors were investigated through a standard questionnaire that included symptoms, medical history, and a clinical examination. Two multivariable models (A and B) were fitted to assess predictors of the diagnosis of CKD. Results: In model A, 9 variables were associated with CKD diagnosis: antenatal ultrasound with urinary malformation, recurrent urinary tract infection, polyuria, abnormal urine stream, nocturia, growth curve flattening, history of hypertension, foamy urine and edema (c-statistic = 0.938). Model B had the same variables as model A, except for the addition of the history of admission during the neonatal period and the exclusion of antenatal ultrasound variables (c-statistic = 0.927). Conclusions: The present scores may serve as a warning sign for CKD diagnosis in children among professionals working in the primary care setting where the symptoms associated with a risk of CKD may be overlooked.
Language: Inglês
CNPq Area: Ciências Sociais Aplicadas
URI: https://pubmed.ncbi.nlm.nih.gov/31002677/
Copyright: O INSPER E ESTE REPOSITÓRIO NÃO DETÊM OS DIREITOS DE USO E REPRODUÇÃO DOS CONTEÚDOS AQUI REGISTRADOS. É RESPONSABILIDADE DOS USUÁRIOS INDIVIDUAIS VERIFICAR OS USOS PERMITIDOS NA FONTE ORIGINAL, RESPEITANDO-SE OS DIREITOS DE AUTOR OU EDITOR
Notes: Texto completo
Appears in Collections:Coleção de Artigos Científicos

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